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Henderson, MD, PhD, Associate Professor, Washington University Clostridioides difficile can cause deadly diarrhea and is the most common healthcare-associated infection in the United States

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it does not alter the level of classical cytosolic Drp1 translocation to the mitochondria 42,72 and is reported to be independent of putative cytosolic mitochondrial fission, promoting GTPases such as Drp1 and Dyn2 72

However, in OXPHOS-deficient cells, the high turnover of mitochondria and the sustained flux of mitochondrial membranes toward other organelles may become increasingly difficult without an adequate dietary lipid intake to replenish those diverted to other cellular structures or used to generate ATP