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Tyurin VA, Balasubramanian K, Winnica D, Tyurina YY, Vikulina AS, He RR et al

Kumari et al., 2019)

Glutathione participates in various physiological processes involved in redox reactions by serving as an electron donor/acceptor

in vitro experiments demonstrated that SGK1 knockdown attenuated erastin-induced downregulation of Slc7a11, GPX4, GSH, and oxidized glutathione (GSSG), while reducing lipid peroxidation, iron accumulation, and mitochondrial damage upregulation, suggesting SGK1's critical role in CHD-associated ferroptosis ( 3.2.3 Role of lipid peroxidation in coronary heart disease ACSL4, a key upstream regulator of lipid peroxidation, has garnered significant attention for its role in ferroptosis