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Abstract Gram-negative bacterial pathogens pose a significant challenge in drug development because their outer membranes hinder the permeation of small molecules

Among others, bacteriophages are key components of the skin microbiome, especially those that target dominant bacterial species such as Cutibacterium , Corynebacterium , and Staphylococcus spp [5]

Recent advances have further expanded the utility of AAV vectors through the integration of gene-editing tools such as CRISPR-Cas9, enabling precise and durable gene correction in vivo

Dosing protocols: TB-500 dosing typically 2-5mg twice weekly (loading phase) for 4-6 weeks then 2-5mg weekly (maintenance phase)