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This has been further supported by both EPM2A and EPM2B knockout mice exhibiting reduced SOD activity in addition to increased levels of lipid peroxidation, suggesting defective cellular processes that reduce oxidative stress by genetic mutations

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To deliver shRNA via adenoviral vectors, 1 10 8 PFU of adenoviral particles (Ad-shBhlhe40 or Ad-shSox9) in 40 l were injected subcutaneously into the exposed dorsal skin 2 d before, on the day of, and 2 d after hair plucking