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doi: 10.1126/sciadv.1601132 [DOI] [PMC free article] [PubMed] [Google Scholar] 82.Trinh VH, Choi JM, Nguyen Huu T, et al

Samples of cells were prepared by diluting exponential phase cells (OD 600 1.52.0) to an OD 600 of 1.0 before washing twice using PBS
Mean smoking pack years was 40.32 35.18

Therefore, it has not yet been possible to overcome the bioavailability barrier by targeting a specific UGT enzyme(s) and/or an efflux transporter(s) of glucuronides