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Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling

Glutathione, a vital cellular antioxidant, plays a crucial role in maintaining cellular health

Proc Natl Acad Sci USA 109:1356113566 Tan CT, Chang HC, Zhou Q, Yu C, Fu NY, Sabapathy K, Yu VC (2021) Moap-1-mediated dissociation of p62/sqstm1 bodies releases keap1 and suppresses nrf2 signaling

Cervicovaginal dysbiosis is thought to exacerbate this process by potentially facilitating HPV acquisition and persistence, and promoting viral transformation (including E6/E7 expression, viral integration, and genomic instability), and supporting secondary infections, such as those caused by Chlamydia trachomatis (Figure 3)