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This is achieved in Complex IV (cytochrome oxidase) using a combination of hemes and copper centers [binuclear copper-A (Cu A ), cytochrome a, cytochrome a 3 , and copper-B] (Fig
[DOI] [PMC free article] [PubMed] [Google Scholar] 110.Bian T, Gardin A, Gemen J, Houben L, Perego C, Lee B, Elad N, Chu Z, Pavan GM and Klajn R, Nat
With this biotransformation, liver detoxification, a long-standing barrier in nanomedicine translation, can be turned into a bridge toward maximizing targeting and minimizing nanotoxicity
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