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IV drips are much faster and more effective than traditional oral remedies, with most patients experiencing symptom improvement within 30 to 60 minutes

[DOI] [PMC free article] [PubMed] [Google Scholar] 18.Khan O

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Simtuzumab as antifibrotic strategy Simtuzumab is a humanised monoclonal antibody against lysyl oxidase-like 2 (LOXL2), which has raised much hope for treatment of fibrosis in both NASH and PSC, since LOXL2 contributes to fibrogenesis by cross-linkage of collagen and regulates bile duct permeability.225 226 In patients with PSC and NASH increased serum levels of LOXL2 correlate with more advanced fibrosis and severity of portal hypertension.226 227 Despite these encouraging findings, simtuzumab failed to show antifibrotic effects in NASH patients with bridging fibrosis or compensated cirrhosis227 and in patients with PSC228 (table 1)