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In addition, a meta-analysis of studies of cancer patients treated with cisplatin found that ACYP2 rs1872328, which plays a role in calcium homeostasis, increased the risk of ototoxicity 4.6-fold (95% CI: 3.07.0), and LRP2 rs4668123 increased the risk of ototoxicity 3.5-fold (95% CI: 1.58.5) (144)

Highly lipophilic compounds have an increased risk of being poorly soluble, quickly metabolized and promiscuous binders, whereas more polar compounds often are less permeable

(2016) Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy

The primary behavioral study performed was the water maze test that consisted of a circular apparatus painted black and filled with water to a depth of 26 cm