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Physiol Rev 84(4):11551228

Patients should seek medical attention if they experience severe or persistent gastrointestinal symptoms, signs of pancreatitis (severe abdominal pain radiating to the back), symptoms of thyroid tumors (neck mass, difficulty swallowing, persistent hoarseness), right upper quadrant pain, jaundice, reduced urine output, or unexplained hypoglycemia
S-nitrosylation can cause the stabilization and the activation of HIF-1 [99] or, conversely, can interfere with the DNA binding and suppress the transcriptional activity of PPAR [100] and of NF-kB [101]

Coordination of circadian clocks in mammals