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Further, activation of the AT 1 receptor results in the stimulation of the NF-kB signal transduction pathway facilitating the synthesis of chemokine, cytokines, and adhesion molecules, all important in the migration of inflammatory cells into regions of tissue injury (107)

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Serine biosynthesis can drive the S-adenosyl methionine (SAM) cycle via one carbon metabolism, thereby fueling the trans-sulfuration pathway and ultimately increasing glutathione production