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doi: 10.1016/j.lwt.2011.02.004

Casadesus et al., Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Although lysosomal pH and cathepsin B activity remained normal, morphological changes after Bafilomycin A1 treatment point to defects in autophagic lysosome reformation (ALR), a cellular process responsible for regenerating functional lysosomes following autophagy, further supporting the role of GDAP1 in PIK fyve -mediated lysosomal maturation

Most mitochondrial proteins are nuclear-encoded and so it is not surprising that the vast majority of mitochondrial diseases are the result of mutations in genes from the nuclear genome