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Liu X, Virk S, Fedorova T, Oo WM, Hunter DJ

For significance testing unpaired Student's t-test was performed with a p-value of 0.05 as significance threshold

Introduction Melatonin is an endogenous indoleamine that is synthesized not only in the pineal gland (endocrine gland located in the posterior area of the cranial fossa in the brain in charge of producing melatonin and serotonin-derived hormones crucial in the modulation of sleep patterns in both circadian and seasonal cycles) but also perhaps in each individual cell, specifically at the mitochondrial level (Yanar et al., 2019)

However, current resources remain fragmented, disease-specific and often restricted to a single modality