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5a), a pro-drug that combines sulphapyridine (an antibiotic) and 5-aminosalicylic (an anti-inflammatory agent) linked by an azo bridge, has huge therapeutic potential, but is, unfortunately, labile under physiological conditions (70% degradation by colonic bacteria via azo cleavage

doi: 10.1046/j.1471-4159.2003.01821.x

In contrast, the gene encoding the sMAF protein MafF is markedly increased in AD, which may partly explain the defect in Nrf2 stimulation (Wang et al

Published by Oxford University Press on behalf of The Gerontological Society of America
