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Exposure evaluation The common approach to evaluate the exposure using HBM data is to convert biomarker measurements into human exposure

Lung Myeloperoxidase (MPO) Activity in Lung Extracts To measure MPO activity, we homogenized the right lungs in 50 mmol/L PBS containing 0.5% hexadecylammonium bromide and 5 mmol/L EDTA (pH = 6.0)

doi: 10.1074/mcp.RA118.000922 174 LinSXLisiLDello RussoCPolakPESharpAWeinbergGet al

Many of the DRL-sorted studies falling within the Valley of Death DRLs 46 separating typical university design research at DRLs 13 from typical industry and government design research at DRLs 79 are greatly facilitated by AI-enhanced computational platforms, including agent-based co-simulation platforms