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For example, it has been reported that CD8 + T cells have facilitated tumor ferroptosis by releasing IFN-, which disrupts the cystine uptake by tumor cells, triggers lipid peroxidation accumulation, and ultimately results in ferroptotic tumor cell death ( + T cells are more sensitive to ferroptosis inducers RSL3 than B16 and MC38 cancer cells ( + T cells underwent lipid peroxidation in lipid laden TME and became dysfunctional (179), targeting lipid peroxidation to enhance cancer therapy must consider the complex nature of TME

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These factors have been confirmed in studies

Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial-mesenchymal transition and modulating SIRT1/-catenin signaling pathway in breast cancer