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Subsequently, to reduce the dosage intervals and enhance the bio availability, the drug releasing pattern of Glibenclamide was modified by forming mucoadhesive beads using sodium alignate and okra gum for drug entrapment, allowing sustained release for up to 8 h in the body [2, 78]

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2.2 Environmental factors Multiple environmental exposures contribute to the onset and progression of UC by altering gut microbiota composition, compromising epithelial barrier integrity, and modulating mucosal immunity