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FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism

Through its genomic actions, the E2ER complex binds to estrogen response elements (EREs) located in the promoter regions of target genes, thereby promoting the transcriptional upregulation of key melanogenic enzymes, including TYR, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2) [37]

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Furthermore, restricted root respiration and phloem transport hinder sugar translocation, causing carbohydrate accumulation in leaves and further suppressing CO 2 assimilation [8, 10]