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It acts as a nitric oxide synthase inhibitor and a competitive inhibitor of guanylate cyclase, impacting multiple cellular signaling pathways

(More information) Lipoic acid occurs naturally in food covalently bound to protein, whereas supplements contain unbound (free) lipoic acid
Inhaled vasoactive intestinal peptide (vip) improves the 6-minute walk test and quality of life in patients with copd: the vip/copd-trial

[DOI] [PMC free article] [PubMed] [Google Scholar] Cheeseman K.H, Slater T.F