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Schoolwerth et al., 1988) (Figure 3A)

doi: 10.3969/j.issn.1673-5374.2012.05.009

Collectively, these data indicate that the significantly reduced Aldh2 activity of Aldh2 KI mice results in elevated toxic aldehydes levels and, especially 4-HNE and increased 4-HNE adduction to proteins involved in mitochondrial reduced FAO and mitochondrial respiration of BAT, leading to markedly decreased FAO rate and mitochondrial respiration and subsequent reduced adaptive thermogenesis and energy expenditure

Abbreviations CCC: Clinical Coordinating Center DLCO: Diffusing capacity for carbon monoxide DSMB: Data and Safety Monitoring Board FDA: Food and Drug Administration FVC: Forced vital capacity GAP: Gender, age, and physiology ILD: Interstitial lung disease IPF: Idiopathic pulmonary fibrosis K-BILD: Kings brief interstitial lung disease NAC: N -Acetylcysteine NHLBI: National Heart Lung and Blood Institute PAMP: Pathogen-associated molecular pattern PANTHER: Prednisone azathioprine and NAC therapy in IPF PFF: Pulmonary Fibrosis Foundation PRECISIONS: Prospective Treatment Efficacy in IPF Using Genotype for NAC Selection SGRQ: St