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High levels of NO can inhibit certain essential enzymes for example, it can interfere with how iron is incorporated into hemoglobin and how liver enzymes (cytochrome P450s) metabolize drugs
it depends on your levels
One notable immunogenicity finding from that same trial is worth highlighting for researchers: antibodies developed in almost 50% of patients receiving tesamorelin, although the study authors noted this was a relatively short-duration trial and did not report this antibody development as being associated with a loss of efficacy or a distinct safety signal within the study period
