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They may cause complications such as: agitation nausea and vomiting high or low heart rate altered consciousness or delirium a sudden change in your thinking and behaviour seizures organ failure heart, lungs, kidneys or liver coma Complications from swallowing some substances can be life-threatening

For these localized applications, systemic absorption may matter less than direct contact with digestive tissues

58,59 Overall, the future research direction of GLP-1RAs involves making them more similar to those in the human body, extending their duration of action, and creating oral formulations for easier administration

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