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Furthermore, the preference of glycolysis over OXPHOS results in a reduction of ROS generation, which in combination with increased stress defense mechanisms, results in extended cell survival with maximal safeguard from genome instability ( 4 Mitochondrial physiology during reprogramming and differentiation Cellular reprogramming requires extensive mitochondrion architectural reorganization and metabolic shift to balance the need for pluripotency and self-renewal

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Xie H, Sun J, Chen Y, Zong M, Li S, Wang Y

BMI-for-age z-scores (zBMI) were calculated using the World Health Organization (WHO) growth charts