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In thalassemia, long-term metabolic inefficiency and systemic stress create a similar state of internal obstruction

However, IL-15-mediated upregulation of ZO-1 and ZO-2 expression was independent of the IL-2R subunit, whereas phosphorylation of occludin and enhanced membrane association of claudin-1 and claudin-2 by IL-15 required the presence of the IL-2R subunit

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Typically, it takes 1 4 weeks to see results, with several injections often recommended in the first two weeks (loading doses) followed by one injection every 3 4 weeks for maintenance