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Description
The activity of MDHAR proteins as well as MDHAR gene expression has been found to be differentially affected by various stress conditions

doi: 10.1186/s12888-021-03130-4

A critical question in understanding these conditions is how the observed metabolite differences in ME/CFS, Fibromyalgia, and GWS compare with those seen in other diseases associated with chronic fatigue or cognitive decline

These two metabolites share a 3-hydroxy-( Z )-pentenyl- cis -epoxide moiety that was identified as the pharmacophore involved in nociceptor sensitization mediation
