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They include: Frequent or urgent need to urinate which increases at night A weak stream Difficulty starting to urinate, or starting and stopping Dribbling stream at the end Inability to empty bladder If you experience any of these symptoms, or especially if you find blood in your urine, you should see your healthcare professional as soon as possible for a diagnosis

Ethics declarations Ethics approval and consent to participate The systematic review and meta-analysis was registered in the PROSPERO database (registration number CRD42022384024)

had one batch that took a while to arrive but product quality has never been an issue

performed and analyzed the western blot and MTT experiments