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Description
IGF-DES is a naturally occurring splice variant that has been artificially optimized for therapeutic use
Long-term outcome in pediatric trichotillomania
VGLUT1 is suggested to be expressed at synapses associated with low release rates and long-term potentiation, while VGLUT2 is expressed at synapses with high release rates and long-term potentiation (Fremeau et al., 2001), with others suggesting VGLUT2 is also associated with synapses displaying long-term depression (Kaneko and Fujiyama, 2002)
Furthermore, E362 is nearby C326 and likely keeps the cysteine reduced for covalent attack of the aldehyde, as evidenced by the reduced activity upon its substitution (E362A)
