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The impact of these lineages can differ based on ethnicity, genetics, and other demographic factors 122

PNPLA3 gene polymorphism is associated with predisposition to and severity of alcoholic liver disease

Drug Metab Dispos 38:22862292 Rahman K, Desai C, Iyer SS, Thorn NE, Kumar P, Liu Y, Smith T, Neish AS, Li H, Tan S, Wu P, Liu X, Yu Y, Farris AB, Nusrat A, Parkos CA, Anania FA (2016) Loss of junctional adhesion molecule A promotes severe steatohepatitis in mice on a diet high in saturated fat, fructose, and cholesterol
