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62 Examples of surfactants are sodium deoxycholate, Cremophor EL, Tween (polyoxyethylene sorbitan monolaurate), Span (sorbitan monolaurate), Solutol HS 15 (polyoxyethylene-660-hydroxystearate), Poloxamer , and sodium dodecyl sulfate

Nonetheless, the addition of bosentan yielded an increase in 6MWD by 7.2 66.0 m in the bosentan group with a reduction of 14.6 80.4 m in the placebo group after 16 weeks

Additional studies have highlighted the neuroprotective effects of other natural compounds, such as benzyl ITC and indole-3-carbinol (not an ITC, but derived from indole glucosinolates), in preclinical models of PD

Several studies have shown that S1P plays a crucial role in tissue fibrosis [21] regulating different aspects, including the permeability of the vascular barrier, the recruitment of inflammatory cells, and the proliferation and differentiation of myofibroblasts, through the transactivation of the TGF- signalling pathway [22]