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This is based on a report that long-term hypothyroidism caused adrenal insufficiency and HPA axis abnormalities (Johnson et al

B12 is a water-soluble vitamin, meaning excess amounts are typically excreted in urine rather than accumulating to toxic levels, which distinguishes it from fat-soluble vitamins like A and D

Acknowledgments Publication of this paper was supported by the University of Medicine and Pharmacy Carol Davila, through the institutional program Publish not Perish

The result may be more pronounced and faster-developing effects on collagen remodeling, tissue repair, and skin quality compared to topical use alone