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10.1016/j.sajb.2009.10.007 South Afr

2006 Dec;27(Suppl 1):7-16

Initially, it seemed improbable to screen over 3,000 analogs only to discover a compound operating through the well-established effector, CRBN, especially one with minimal independent affinity for the ligase

The microtubule-associated protein Tau ( MAPT ) gene, which is involved in stabilization of cytoskeleton and subsequent facilitation of the transport of neurotransmitters, has also been found as a locus associated with genetic risk for PD (Satake et al., Parkin (Kitada et al., PINK1 (Valente et al., 2004), both of which are involved in familial PD, are genes involved in mitophagy