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immunohistochemistry showed that BNIP3L/NIX levels in these cells were significantly decreased in aged mouse cochlea, accompanied by increased expression of TOMM20, p62, and LC3B, which indicates an accumulation of dysfunctional mitochondria and a lack of mitophagy (Kim et al., 2021)
Seven novel deleterious LEPR mutations found in early-onset obesity: a Exon6-8 shared by subjects from Reunion Island, France, suggests a founder effect
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