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Sickle cell disease is a common hereditary hemoglobinopathy caused by a point mutation in -globin that promotes the polymerization of deoxygenated hemoglobin, leading to red cell distortion, hemolytic anemia, microvascular obstruction, and ischemic tissue damage

However, only Zileuton was approved for clinical therapy, which is believed to ligate the active iron through its N-hydroxy urea moiety [267]

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