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Current serotonin medications are aimed at increasing central 5-HT neurotransmission in the brain, and there are no approved indications for manipulating peripheral 5-HT, though peripheral 5-HT synthesis is being considered as a potential target for developing pharmacological agents in some disorders ( We are not aware of prior studies reporting low S-5-HT in hypothyroidism or CFS

Individuals with specific allele combinations have two-fold lower baseline CRP levels, possibly due to subsequent DNA structural changes that have an impact on transcription [48]

Utilize bloodwork to customize micronutrient needs and fill gaps with targeted supplementation if necessary

Narrow dental arches, crowded teeth, and underdeveloped jaws can reduce the space available for airflow, especially when muscles relax during sleep