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Brain cavitation and micrencephaly in lambs exposed to prenatal hyperthermia

Abstract Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and associated mechanisms that alter chromatin in response to physiological or pathological signals have transformed our knowledge of epigenetics from a collection of curious biological phenomena to a functionally dissected research field

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533 Topical agents such as the capsaicin 8% patch provide localized pain relief by desensitizing nociceptive fibers, while the lidocaine patch 5% is useful for focal neuropathic pain with a favorable safety profile