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Approximately 50% to 98% of the injected cyanocobalamin is in the urine

In the CNS, thiamine deficiency can lead to Wernickes encephalopathy, characterized by nystagmus, ophthalmoplegia, mental status changes, and unsteady stance and gait, due to apoptotic cell death in sensitive brain areas, mainly areas with high metabolic requirement, causing symmetrically distributed lesions among structures such as the third and fourth ventricles, besides dorsomedial thalamus (, , )

Gut microbiota dysbiosis contributes to the development of hypertension

Contraceptive Interactions Because GLP-1 RAs slow gastric emptying, they may decrease absorption of oral contraceptives, particularly during dose escalation phases