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Description
The large-scale STEP clinical trials (Semaglutide Treatment Effect in People with Obesity), published in the New England Journal of Medicine and JAMA, did not report increased cold sensitivity as a significant adverse effect

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Excess Fe 2+ is exported via ferroportin (FPN) to maintain intracellular iron homeostasis (Wang et al., 2025d

The precise underlying cause of Mnire disease is not yet clear
