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Alcohol deserves a mention as well

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[13] This research primarily focused on the peptide's potential impact on dermal procollagen synthesis, the proliferation and differentiation of keratinocytes (the predominant cell type in the epidermis), and cutaneous inflammation

Though the exact mechanism is not well understood, it is thought that estrogen deficiency leads to down regulation of the expression of transcellular calcium transport proteins plasma membrane calcium pump 1b (PMCA1b), transient receptor potential cation channel subfamily V member 5 (TRPV5) and calbindin-D 28K (CaBP28k) [95]