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High cortisol levels can interfere with muscle building and fat loss by promoting catabolism (the breakdown of muscle tissue)
BNIP3 or BNIP3L deficiency was found to restrain ischemia-related mitophagy, demonstrating their crucial role in mitochondrial hypoxic adaptation [58, 59]

But dont wait for the consensus to change soon

Hinterseher et al., 2015)