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These findings highlight the fact that not all PAMs of a given receptor behave similarly in vivo , which must be taken into account when designing studies evaluating their therapeutic potential

Mood Disorders Both glutamate overactivity and reduced GABAergic signaling are implicated in mood disorders such as depression and bipolar disorder

Sci Rep 11(1):11107 Acknowledgements We are grateful to our Department of Human Genetics, Sri Ramachandra Institute of Higher Education and Research