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The putative endothelium-derived relaxing factor, S-nitroso-L-cysteine, a stab1e deaminated analog of S-nitroso-L-cysteine, S-nitroso-3-mercaptoproprionic acid and sodium nitroprusside produced concentration-dependent (1-100 uM) increase (1.5- to 12-fold) in rabbit pulmonary arterial smooth muscle cells cyclic guanosine monophospate levels

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Substrate specificity of TGM As KCs terminally differentiate into corneocytes, an early step in the formation of the cornified envelope is an attachment of involucrin to the inner surface of the cell membrane in a reaction catalyzed by the essential enzyme, TGM1 (Candi et al., 2005