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doi: 10.1016/j.ophtha.2011.01.041

In participants with moderate-to-severe cognitive impairment (defined by MMSE), a larger improvement in cognitive performance was observed for donepezil and memantine, and their combination (donepezil +memantine), and these efficacy-related results are expected to also be reflected when a future study becomes available
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Avoid repeated freeze-thaw cycles, as thermal stress can cause peptide degradation and loss of biological activity
