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6.5 Corneal disorders Studies have demonstrated that decreased levels of GPX4 in HCECs can lead to increased LDH levels, which can trigger ferroptosis (150)

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For example, Papokastas and colleagues 5 found that treatment of major depressive disorder (MDD) with 15mg of Lmethylfolate in conjunction with an SSRI showed significantly greater efficacy compared to SSRI therapy alone regarding response rate and degree of change in depression symptom scores

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