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Unsaturated ketones appear to be related to the mechanisms causing these effects, and these regions are known to form covalent bonds via a Michael addition reaction with the thiol groups of cysteine residues, and this also could be due to the antioxidant enzyme thioredoxin reductase that may be altered by this method, resulting in the formation of ROS (293)

Only bacteriostatic water or sterile water for injection is acceptable

Free iron that remains unsequestered or unexported can participate in the Fenton reaction, generating hydroxyl radicals and ultimately promoting increased reactive oxygen species (ROS) production and enhanced lipid peroxidation

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