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glutathione peroxidase pronounce s transferase oxidative stress Figure 1 from Glutathione S-transferase, catalase, superoxide dismutase, glutathione 1: Detoxification of oxidizing species.
Description
The aforementioned pathways result in the production of free radicals, and changes in the maintenance of oxidative stress and cellular energy, all of which collectively cause cell death

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In FRDA, NRF2 is typically downregulated, however, treating afflicted fibroblasts with NRF2 inducers like EPI-743 and sulforaphane could rectify iron deficiency and redox imbalance by targeting NRF2-mediated iron homeostasis [809, 810]
Both have similar side effects and carry a risk of dependence
