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Such a framework would not only validate the threshold effect identified herein but also clarify whether B12 supplementation in deficient women improves IVF outcomes and whether genetic factors modify this relationship

[iv] Dupont, J., & LeRoith, D

B12-downregulated genes in this group were related to positive regulation of transcription by RNA polymerase II, processing and transport of mRNA, mRNA splicing, cellular response to DNA damage stimulus, activation of innate immune response, positive regulation of IL-6 and IL-2 production, T-cell differentiation in thymus, histone modification, viral transcription and DNA conformational change

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