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In patients with gastroesophageal or CRCs, incidence of c-Met mutations is only 12% and 25% (Zeng et al., 2008)
This effect was associated with increased expression of IGF-1 and VEGF in the primary ossification zone.103 Altogether, the bone anabolic actions of the GH can be, at least in part, mediated by paracrine IGF-1 signaling, which enhances osteoblast activity.104 In fact, the only administration of recombinant IGF-1 to healthy participants results in an increase in circulating levels of bone remodeling markers
Irigoyen, P., Mansilla, S., Castro, L., Cassina, A
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