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Preclinical evidence Mice with a deletion of the 22q11.2 locus containing most proteins expressed in mitochondria [19] show increased cytoplasmic 8-oxo-2-deoxyguanosine (suggesting mitochondrial DNA oxidation), reduced number of PV-immunoreactive interneurons, and weakened PNN in anterior cingulate cortex [15]

Based on the molecular docking results above, we hypothesized that Ag might promote ferritinophagy by interacting with NCOA4

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