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(2024) Characterizing the Causal Role of SVEP1 in Human Disease

When detoxification capacity is overwhelmed: Oxidative stress rises Mitochondrial efficiency declines Cellular recovery slows Pain sensitivity increases This creates a compounding effect: impaired detoxification further strains nutrient reserves, and diminished nutrient reserves reduce detox efficiency

Dieterle F, Sistare F, Goodsaid F et al (2010b) Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium
