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The remaining follicle cells transform into a progesterone-secreting structure called the corpus luteum

In spite of the aetiological bases of infertility, epigenetic alterations that occur on account of infertility treatment play a role in chronic longer-term diseases, involving differential methylation of genes vital for development and growth with longer-term implications pertaining to health (Reference Pisarska, Chan and Lawrenson28)

For the same reasons, female participants were advised to promptly inform the investigators in case of a suspected pregnancy, to be withdrawn from the study and to assess treatment continuation on a case-by-case basis

Similarly, online questionnaires have found a high prevalence of migraine-like headaches among patients with mitochondrial disease (66)